The Datta dynasty and Mitra dynasty soon followed in Mathura.The Indo-Greeks ultimately disappeared as a political entity around 10 AD following the invasions of the Indo-Scythians, although pockets of Greek populations probably remained for several centuries longer under the subsequent rule of the Indo-Parthians and Kushans.
After 321 BC Eudemus toppled Taxiles, until he left India in 316 BC.
To the south, another general also ruled over the Greek colonies of the Indus: Peithon, son of Agenor, until his departure for Babylon in 316 BC.
The Greeks in the Indian Subcontinent were eventually divided from the Graeco-Bactrians centered in Bactria (now the border between Afghanistan and Uzbekistan), and the Indo-Greeks in the present-day north-western Indian Subcontinent.
The most famous Indo-Greek ruler was Menander (Milinda).
Accordingly, Seleucus ceded to Chandragupta his northwestern territories, possibly as far as Arachosia and received 500 war elephants (which played a key role in the victory of Seleucus at the Battle of Ipsus): The Indians occupy in part some of the countries situated along the Indus, which formerly belonged to the Persians: Alexander deprived the Ariani of them, and established there settlements of his own.
But Seleucus Nicator gave them to Sandrocottus in consequence of a marriage contract, and received in return five hundred elephants.During the two centuries of their rule, the Indo-Greek kings combined the Greek and Indian languages and symbols, as seen on their coins, and blended Greek and Indian ideas, as seen in the archaeological remains. His son, Demetrius I, founder of the Indo-Greek kingdom, was therefore of Greek ethnicity at least by his father.A marriage treaty was arranged for the same Demetrius with a daughter of the Seleucid ruler Antiochus III (who had some Persian descent).Chandragupta's grandson Ashoka, who had converted to the Buddhist faith declared in the Edicts of Ashoka, set in stone, some of them written in Greek, Here in the king's domain among the Greeks, the Kambojas, the Nabhakas, the Nabhapamkits, the Bhojas, the Pitinikas, the Andhras and the Palidas, everywhere people are following Beloved-of-the-Gods' instructions in Dharma.Some Greeks (Yavanas) may have played an administrative role in the territories ruled by Ashoka: the Junagadh rock inscription of Rudradaman records that during the rule of Ashoka, a Yavana King/ Governor named Tushaspha was in charge in the area of Girnar, Gujarat, mentioning his role in the construction of a water reservoir.He had his capital at Sakala in the Punjab (present-day Sialkot).